Our Vision

Advancing critical care at the intersection of physiology, engineering, and intelligent systems.

At the forefront of critical care innovation, the ASPIRE Lab brings together physician-scientists, surgeons, engineers, and clinical researchers dedicated to transforming how we respond to the most severe forms of shock and organ failure. Our work spans clinical expertise in critical illness and advanced mechanical support, computational modeling of complex physiology, small and large animal models of disease, and medical device prototyping and fabrication. These capabilities are united by a shared mission: to develop and translate medical technologies, from automated shock resuscitation systems to advanced ECMO platforms, into lifesaving solutions.

The lab is led by Dr. Steve Keller, a physician-engineer in the Division of Pulmonary and Critical Care Medicine whose work centers on mechanical circulatory and respiratory support. Supported by a dynamic team of postdoctoral fellows, graduate students, and research staff, we are redefining the future of resuscitation science and extracorporeal support.

Our Approach

We develop intelligent, automated systems that support and extend life-saving interventions. By integrating physiological modeling, real-time monitoring, and adaptive control, we work to improve outcomes in shock, respiratory failure, and acute care. Across every project, our research bridges engineering and medicine to deliver innovative, patient-centered solutions.

Our Philosophy

We believe the best science is both rigorous and joyful. We hold our work to a high standard, ask hard questions, and pursue problems that matter, while keeping the curiosity and creativity that make discovery worth doing. We are builders at heart, drawn to bold ideas and willing to take the risks that real innovation requires. Much of our work is collaborative by nature: our projects draw on expertise across many people, and we expect lab members to work closely together and share in the process of discovery. Above all, we are committed to the growth of the people in our lab. We see mentorship as central to our mission, and we work to help every trainee develop the skills, independence, and scientific judgment to thrive, here and throughout the careers ahead of them.